An 8-year-old girl was brought to her pediatrician because her parents noted frequent episodes of gait unsteadiness and speech difficulties.

An 8-year-old girl was brought to her pediatrician because her parents noted frequent episodes of gait unsteadiness and speech difficulties. Her mother was concerned because of a family history of Friedreich ataxia. Which of the following is a correct description of connections involving cerebellar neurons?

A. Basket cells release glutamate to activate Purkinje cells.

B. Climbing fiber inputs exert a strong excitatory effect on Purkinje cells, and mossy fiber inputs exert a strong inhibitory effect on Purkinje cells.

C. Granule cells release glutamate to excite basket cells and stellate cells.

D. The axons of Purkinje cells are the sole output of the cerebellar cortex, and they release glutamate to excite the deep cerebellar nuclei.

E. Golgi cells are inhibited by mossy fiber collaterals.

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