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A 57-year-old woman, scheduled for an elective hysterectomy, is referred for management of her anticoagulation during the perioperative period. She is currently receiving warfarin 3 mg daily for a 5-year history of atrial fibrillation with past evidence of a single embolic event. Other medical problems include hypertension and diabetes, controlled with an angiotensin-converting enzyme (ACE) inhibitor and diet. She also takes a baby aspirin each day. Examination reveals a healthy black female with no complaints. Positive findings on examination include an irregularly irregular heart rhythm and a faint diastolic murmur Vital signs: BP – 1 55/80 mm Hg, pulse – 75 bpm, resp – 1 6/min, T – 3rc. Coagu lation studies: Platelet count = 21 0,000/J.LL PT = 25. 1 seconds (< 14=”” seconds)=”” inr=”2.4″ (0.8-=”” 1=”” .3)=”” ptt=”29″ seconds=”” (22-35=”” seconds)=”” question=”” •=”” given=”” the=”” potential=”” for=”” significant=”” hemorrhage=”” during=”” surgery,=”” how=”” should=”” this=”” patient=”” be=””>

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